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2016 Jul;44(5):749-762. Cumene hydroperoxide (CHP) is a high production volume chemical that is used to generate phenol and acetone. The free-radical inhibitors may include phenolic compounds such a hydroquinone, p-methoxyphenol, pyrogallol, etc. NTP Technical Report on the metabolism, toxicity and predicted carcinogenicity of diazoaminobenzene (CAS No. Appl. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780124058828000027, URL: https://www.sciencedirect.com/science/article/pii/B9780444533494001242, URL: https://www.sciencedirect.com/science/article/pii/B9780128136911000166, URL: https://www.sciencedirect.com/science/article/pii/B9780123864543005996, URL: https://www.sciencedirect.com/science/article/pii/B9780080951676005048, URL: https://www.sciencedirect.com/science/article/pii/S0921042302800247, URL: https://www.sciencedirect.com/science/article/pii/S0076687902470371, URL: https://www.sciencedirect.com/science/article/pii/B0123693977000054, URL: https://www.sciencedirect.com/science/article/pii/S0076687902470231, URL: https://www.sciencedirect.com/science/article/pii/S0076687910740015, Reduced Nicotinamide Adenine Dinucleotide Phosphate, Hydrogen Peroxide and cell signaling, Part B, Kimberly J. Nelson, ... Leslie B. Poole, in, Ring-Opening Polymerization and Special Polymerization Processes, Polymer Science: A Comprehensive Reference, studied the effect of encapsulating the initiator, Carbonaceous nanostructures in hydrocarbons and polymeric aerobic oxidation mediums, Eldar Zeynalov, ... Matanat Magerramova, in. Karin Fackler, ... Kurt Messner, in Progress in Biotechnology, 2002. No significant changes in survival or body weight of mice and rats were observed following 14 days of exposure. Copyright © 2020 Elsevier B.V. or its licensors or contributors. In World Environmental Congress (WORLD’95): Promoting the Science, Technology and Business of Environment, Int. 2010, 132(16), 5886–5895, with permission from American Chemical Society. Biophys. Vol. The niobium(salan) complexes can be prepared in situ from Nb(OPri)5 and the corresponding salan ligands 11–13 and directly used without isolation and purification. With CHP, the kappa number was reduced to 7.7 (52% kappa reduction) demonstrating the much stronger oxidative reaction that is initiated by this system. Part of Springer Nature. 1995 Aug;14(4):317-24. doi: 10.1080/07315724.1995.10718516. Technol. Seed J L, Cadet J, Nagamatsu T, Wang S Y and Bueding E 1981 The mutagenic activity of cumene, thymidine and thymine hydroperoxides and their derivatives. 30, 596–599. In conclusion, topical CHP application caused skin damage only at the application site and did not cause systemic tissue impairment. 20.11.95, Bul.  |  Impact of apple polyphenols on GSTT2 gene expression, subsequent protection of DNA and modulation of proliferation using LT97 human colon adenoma cells. Lazarev N V and Levina E N (Eds.) TPx-1 assays can be carried out at 25° in 1 ml of assay mixture consisting of 50 mM HEPES (pH 7.2), 10 µM PfTrx-1,100 µM NADPH, Pf TrxR at ∼50 mU/ml (care should be taken that the Pf TrxR concentration is not rate limiting), and 200 µM H2O2, tBOOH, or cumene hydroperoxide. RsbT and RsbV contribute to sigmaB-dependent survival under environmental, energy, and intracellular stress conditions in Listeria monocytogenes. Natl Toxicol Program Tech Rep Ser. Toxicology and carcinogenesis studies of androstenedione (CAS No. Williams and Wilkins, Baltimore, MD, USA, pp. The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells. 2007 Feb;(523):1-286. 1974 Bergey’s Manual of Determinative Bacteriology. NIH 29, 532–537. Effect of natural phenolic acids on DNA oxidation in vitro. Cold Spring Harbor Laboratory, NY, USA, 1972 ). Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Asthma and oxidant stress: nutritional, environmental, and genetic risk factors. See this image and copyright information in PMC. The .gov means it's official. Ergosterol oxidation may be considered a signal for fungal growth and aflatoxin production in Aspergillus parasiticus. Lenhard G 1965 Dehydrogenase activity as criterion for the determination of toxic effects on biological purification systems. In summary our data suggest that Myrica nagi is an effective chemopreventive agent in skin and capable of ameliorating cumene hydroperoxide-induced cutaneous oxidative stress and toxicity. 1246. Reproduced from Egami, H.; Oguma, T.; Katsuki, T. J. Occasionally, other reducing agents including acylhydrazines and mercaptans may also be used. Amino acid and protein scavenging of radicals generated by iron/hydroperoxide system: an electron spin resonance spin trapping study.  Completed, Salmonella  Note inflammatory cells throughout the dermis. 528. This process is experimental and the keywords may be updated as the learning algorithm improves. Microbiol. When determining an apparent Km in a Lineweaver−Burk plot in the presence of 4 to 200 µM H2O2, a Km value of 10 µM is determined in the presence of 5 µM PfTrx, a value of 17 µM is determined in the presence of 10 µM PfTrx, and 41 µM in the presence of 20 µM PfTrx. Get the latest public health information from CDC: https://www.coronavirus.gov. The role of NADPH in the regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in rat adipose tissue. colorless to pale yellow clear liquid (est), 225.00 to 226.00 °C. We continuously strive to advance our technology. Liangwei Zhong, Arne Holmgren, in Methods in Enzymology, 2002. Ames assay; industrial chemical; oxidizing agent; skin irritant. 1D. 2E. Modulation of biochemical parameters by Hemidesmus indicus in cumene hydroperoxide-induced murine skin: possible role in protection against free radicals-induced cutaneous oxidative stress and tumor promotion. Appl. Cumene hydroperoxide (CHPO) is the noxious environmental pollutant whose toxicity is determined both by hydroperoxide and aromatic structures. 20% Aromatic Hydrocarbon), C2223 Cumene Hydroperoxide (contains ca. from J H Miller, Experiments in Molecular Genetics. China Catalog of Hazardous chemicals 2015: Listed. Leonard, K. Quigley, in Encyclopedia of Analytical Science (Second Edition), 2005. In recent years, considerable efforts have been made to identify new chemopreventive agents which could be useful for man. The protective effect of Myrica nagi was dose-dependent. Oxidative stress can lead to DNA damage and mutations, lipid peroxidation, the disassembly of iron–sulfur clusters, disulfide bond formation, and other types of protein oxidation.25 It is known that thioredoxins and glutaredox-ins via reduced glutathione (GSH) are required for disulfide bond reduction and for glutathione- and thioredoxin-dependent peroxidase activities, and the GSH- and thioredoxin-based systems have been proposed to protect cells against oxidative stress.26 Lipid hydroperoxides can accumulate in tissues and exert harmful effects. Biol., Prague, 4–4. 2019 May 31;8(6):149. doi: 10.3390/plants8060149. Microbiol. Ethylenediaminetetraacetic acid (EDTA) and its various analogs tend to be the preferred type. In T Macek, K Demnerova and M Mackova (Eds.). 2 weeks (Topical Application) (C99029) Completed . COVID-19 is an emerging, rapidly evolving situation. PubMed:Iron-accelerated cumene hydroperoxide decomposition in hexadecane and trilaurin emulsions. However, 90 days of CHP exposure at the high dose (12 mg/kg) triggered a significant decrease (-15%) in the body weight of the male rat group only. 8, 121–125. Soc. (A97584) Cumene Revision Date 19-Jan-2018 Cumene 98-82-8 >95 4. Fedorov A Yu, Korzhenevich V I, Mironov A D, Krestyaninov V Yu and Gumenyuk A P 1992 Bacterial utilization of phenolic wastewater components. These keywords were added by machine and not by the authors. Dermal exposure to CHP was hypothesized to result in systemic tissue toxicity, production of free radicals, and consequent decrease in plasma antioxidant levels. Fedorov A Yu, Volchenko E V, Him N V, Krestyaninov V Yu and Voronin S P 1993 Toxic effect of isopropylbenzene hydroperoxide on active sludge microorganisms. Group nomination for salmonella, part 2 (N81364), National Institute of Environmental Health Sciences, Testing Status of Cumene hydroperoxide M200035, 2 weeks (Topical Application)   |  Toxicology studies of trimethylolpropane triacrylate (technical grade) (CAS No. Hair follicle hyperplasia in a female mouse characterized by increased number of follicles within the dermis extending into the subcutis (arrows). Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Epub 2014 May 8. Exudate in a male rat characterized by marked accumulation of successive layers of proteinaceous fluid, keratin and degenerate neutrophils on the surface of the hyperplastic epidermis (arrows). 3524-68-3) in F344/N rats, B6C3F1 mice, and genetically modified (FVB Tg.AC hemizygous) mice (dermal studies). Fedorov A Yu, Volchenko E V, Singircev I N, Romanova T A and Shoob G M 1995 Microbial degradation of cumene hydroperoxide. Consistent with the lack of systemic damage, no increase in micronucleated erythrocytes was seen in peripheral blood. The cure systems typically incorporate an organic peroxide, an organic reducing agent, and an organic acid. Russian patent. The selectivity of the process, however, was much lower than in the coordinated copper system with H2O2. (A82256) Kabra A, Martins N, Sharma R, Kabra R, Baghel US. Application of simulation modeling to lipid peroxidation processes.  Completed. PubMed: Male-mediated dominant lethal mutations in mice following prooxidant treatment. This service is more advanced with JavaScript available, Global Environmental Biotechnology Note epidermal hyperplasia and sebaceous gland hyperplasia.

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